Experiment 458179
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | DAS,SK: PARIA,BC: ANDREWS,GK: DEY,SK:. (1993). EFFECTS OF 9-ENE-TETRAHYDROCANNABINOL ON EXPRESSION OF BETA-TYPE TRANSFORMING GROWTH FACTORS, INSULIN-LIKE GROWTH FACTOR-I AND C-MYC GENES IN THE MOUSE UTERUS.. 45(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | CMPD ALTERED TIMING OF 17-BETA-ESTRADIOL-INDUCED INCREASE IN TRANFORMING GROWTH FACTOR BETA3 MRNA FROM 24 TO 12 HRS POST TREATMENT. CMPD ALSO ENHANCED TGF-BETA2 MRNA INCREASE INDUCED BY ESTRADIOL WITHOUT ALTERING TIMING. ESTRADIOL-INDUCED INCREASE IN INSULIN-LIKE GROWTH FACTOR-I WAS ALTERED AS TO TIMING BYCMPD AS WAS RATE OF INDUCED INCREASE IN C-MYC MRNA. SIMILAR EFFECTS BROUGHT ABOUT BY PROGESTERONE. BUT NOT AFFECTED BY CMPD. THUS CMPD HAS ESTROGENIC AND ANTIESTROGENIC EFFECTS. |
| Dose amount | 2.5 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |