Experiment 470703
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | LETEURTRE,F: FESEN,M: KOHLHAGEN,G: KOHN,KW: POMMIER,Y:. (1993). SPECIFIC INTERACTION OF CAMPTOTHECIN, A TOPOISOMERASE I INHIBITOR, WITH GUANINE RESIDUES ON DNA DETECTED BY PHOTOACTIVATION AT 365 NM.. 32(34) |
| Amount utilized | |
| Compound isolated | |
| Disease | CMPD INDUCED SINGLE STRAND BREAKS AFTER UV IRRADIATION AT SITES HAVING GUANINE AT THE 5' END. EFFECT DECREASED BY DIDEOXYGUANOSINE TRIPHOSPHATES AND NA+ MG 2+ SHIELDING OF GROOVE. SPERMIDINE ENHANCED EFFECT. IN AEROBIC CONDITIONS, THIOUREA, SODIUM AZIDF AND CATALASE WERE MORE PROTECTIVE THAN SUPEROXIDE DISMUTASE OR MANNITOL. AN AEROBIC CONDITIONS YIELDED MORE BREAKS THAN AEROBIC. |
| Dose amount | 00.0 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | IC100 |