Experiment 473284

Details

PropertyValue
Pharmacology
Administration routeIP
OrganismEmpty organism
CitationFAVRE,G:. (1992). INCORPORATION OF LOW DENSITY LIPOPROTEIN INTO CANCER CELLS. APPLICATION OF DERIVATIVES OF ELLIPTICINE.. 186(1/2)
Amount utilized
Compound isolated
DiseaseTHE DRUG-LDL COMPLEX EXPRESSED SIMILAR METABOLIC ACTIVITY, IN VITRO AND IN VIVO, THAN NATIVE LDL. INITIAL EXPERIMENTS WITH MELANOMA B16 TUMOR-BEARING MICE SUGGEST THAT LDL MAY BE POTENTIAL DRUG CARRIER IN THE TREATMENT OF MALIGNANT DISEASES. THE KNOWLEDGE OF THE MOLECULAR MECHANISM OF THE EXPRESSION OF THE LDL RECEPTOR IN TUMOR CELLS AND THE ABILITY TO DOWNREGULATE THE LDL RECEPTOR IN THE NORMAL TISSUES, WILL DEFINE THE APPLICATION FIELD OF THIS TARGETTING APPROACH.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalMOUSE
Dose expressionDOSE