Experiment 473359

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

STREPTOMYCES ANTIBIOTIC R-1128-B

Details

PropertyValue
Pharmacology
COLONY FORMATION INHIBITION
OrganismEmpty organism
CitationHORI,Y: ABE,Y: NISHIMURA,M: GOTO,T: OKUHARA,M: KOHSAKA,M:. (1993). R1128 SUBSTANCES, NOVEL NON-STEROIDAL ESTROGEN-RECEPTOR ANTAGONISTS PRODUCED BY A STREPTOMYCES. III. PHARMACOLOGICAL PROPERTIES AND ANTITUMOR ACTIVITIES.. 46(7)
Amount utilized
Compound isolated
DiseaseCELL COLONY FORMATION AGAINST THE EXTROGEN-RESPONSIVE CELL MCF-7 WAS INHIBITED IN A DOSE DEPENDENT MANNER. THE RESULTS SUGGEST AN ESTROGEN RECEPTOR ANTAGONIST EFFECT.
Dose amount0.54 MICROMOLS
Number4
Qualitative resultACTIVE
AnimalCELL CULTURE
Dose expressionIC50