Experiment 47461
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | SC |
| Organism | Echinacea purpurea (ASTERACEAE) |
| Citation | KOCH,E: UEBEL,H:. (1953). EXPERIMENTAL STUDY CONCERNING THE LOCAL ACTION OF ECHINACEA PURPUREA ON TISSUES.. 3() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE COMMERCIAL PRODUCT ECHINACIN WAS TESTED. THE ANTIINFECTIOUS ACTIVITY OF THE EXTRACT IN INFECTIONS OF GUINEA PIGS WITH STREPTOCOCCI WAS STUDIED. PRETREATMENT OF THE SUBCUTANEOUS TISSUE OF THE ANIMALS WITH THE EXTRACT CAUSED A RETARDATION AND LOCALIZATION OF THE INFECTIONS. PRETREATMENT WITH FORMALIN CAUSED A RAPID SPREADING WHICH WAS FATAL IN MOST CASES. IT WAS CONCLUDED THAT THE PROTECTIVE ACTION OF THE EXTRACT WAS BASED ON AN INACTIVATION OF HYALURONIDASE AND INDIRECT INCREASE IN FIBROBLASTS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | GUINEA PIG |
| Dose expression | DOSE |
| Extract | H2O EXT |