Experiment 478628

Details

PropertyValue
Pharmacology
Administration routeINTRAGASTRIC
OrganismEmpty organism
CitationMENGS,U: STOTZEM,CD:. (1993). RENAL TOXICITY OF ARISTOLOCHIC ACID IN RATS AS AN EXAMPLE OF NEPHROTOXICITY TESTING IN ROUTINE TOXICOLOGY.. 67(5)
Amount utilized
Compound isolated
DiseaseRATS SHOWED RENAL LESIONS WITHIN 3 DAYS OF A SINGLE DOSE. HISTOLOGICALLY, THERE WAS EVIDENCE OF NECROSIS OF THE EPITHELIUM OF THE RENAL TUBULES. RATS ALSO SHOWED A RISE IN PLASMA CREATININE AND UREA TOGETHER WITH INCREASES IN URINARY GLUCOSE, PROTEIN, N-ACETYL-BETA-GLUCOSAMINIDASE, GAMMA GLUTAMYL TRANSFERASE AND MALATE DEHYDROGENASE.
Dose amount100.0 MG
Number1
Qualitative resultACTIVE
AnimalRAT
Per unitKG
Dose expressionDOSE