Experiment 480370
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | WANG,BJ: SHEN,XM: ZHOU,YH: CHEN,SP: CHENG,K: GONG,F: XIAO,YF: CHEN,KQ: CHEN,XM:. (1992). EFFECTS OF GTW AND T-4 FROM TRIPTERYGIUM WILFORDII HOOK F. ON LH CELLS IN MALE RAT PITUITARY GLANDS.. 14(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | USING ANTI-BETA-LH MONOCLONAL ANTIBODIES, STUDIES WERE UNDERTAKEN TO ASSESS THE EFFECTS OF GTW AND TRIPCHLOROLIDE ON LH CELLS IN MALE RAT PITUITARY GLANDS, USING IMMUNOHISTOCHEMICAL METHODS AND ULTRASTRUCTURAL OBSERVATION. THE RESULTS SHOWED THAT THERE WERE MORE VACUOLES IN THE CYTOPLASM OF LH CELLS AND THE COLOR DENSITY OF IMMUNOHISTOCHEMICAL STAINING WAS MUCH STRONGER IN THE TREATED GROUPS THAN THAT IN THE CONTROLS. ELECTRON MICROSCOPY STUDIES SHOWED THAT THE NUCLEI OF LH CELLS WERE SHRUNKEN AND THE GOLGI COMPLEXES AND THE ROUGH ENDOPLASMIC RETICULA WERE LARGELY EXPANDED IN THE TREATED GROUPS. THE MECHANISM OF THESE CHANGES IS SIMILAR TO THAT IN CASTRATION CELLS. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | CONC USED |
| Gender | MALE |