Experiment 480494
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | PHILIP,PA: REA,D: THAVASU,P: CARMICHAEL,J: STUART,NSA: ROCKETT,H: TALBOT,DC: GANESAN,T: PETTIT,GR: BALKWILL,F: HARRIS,AL:. (1993). PHASE I STUDY OF BRYOSTATIN 1: ASSESSMENT OF INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR ALPHA INDUCTION IN VIVO.. 85(22) |
| Amount utilized | |
| Compound isolated | |
| Disease | 35 PATIENTS WITH VARIOUS MALIGNANT TUMORS WERE TREATED IN THIS PHASE 2 STUDY. PATIENTS WERE GIVEN DOSES RANGING FROM 25-50 MCG/SQ.M. FOR VARIOUS COURSES. DOSE LIMITING TOXICITY WAS MYALGIA. PATIENTS ALSO EXPERIENCED SKIN FLUSHING,DYSPINEA, HYPOTENSION AND BRADYCARDIA. TWO PATIENTS WITH METASTATIC MALIGNANT MELANOMA HAD PARTIAL REMISSION. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |