Experiment 480791
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | NIGRA,L: HUXTABLE,RJ:. (1992). HEPATIC GLUTATHIONE CONCENTRATIONS AND THE RELEASE OF PYRROLIC METABOLITES OF THE PYRROLIZIDINE ALKALOIDS, MONOCROTALINE, FROM THE ISOLATIED PERFUSED LIVER.. 30(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | COMPOUND METABOLIZED TO PYRROLIC METABOLITES EXCRETED IN BILE, THE COMMONEST BEING 7-GLUTATHIONYLDEHYDRORETRONECINE. PHENOBARBITAL PRETREATMENT ENHANCES EFFECT, WHILE CHLOROETHANOL, WHICH REACTS WITH GLUTATIONE, DECREASES LEVELS OF METABOLITES. BUTHIONE SULFOXIMINE, WHICH INHIBITS GLUTATHIONE SYNTHESIS, ALSO DECREASES LIVER LEVELS OF GSH BUT DOES NOT DECREASE METABOLITE LEVELS. |
| Dose amount | 300.0 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |