Experiment 481209
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Empty organism |
| Citation | BRANNAN,T: MARTINEZ-TICA,J: YAHR,MD:. (1991). EFFECT OF YOHIMBINE ON BRAIN MONOAMINES: AN IN VIVO STUDY.. 3(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | FOLLOWING THE ADMINISTRATION OF YOHIMBINE, AN ALPHA-2-ADRENORECEPTOR ANTAGONIST, THE LEVELS OF NOREPINEPHRINE (NE), DIHYDROXYPHENYLACETIC ACID (DO-PAC), HOMOVANILLIC ACID (HVA), AND 5-HYDROXYINDOLEACETIC ACID (5HIAA) INCREASED SIGNIFICANTLY IN THE LATERAL VENTRICULAR FLUID OF RATS. THESE INCREASES WERE ABOLISHED WHEN ANIMALS WERE PRETREATED WITH ALPHA-METHYL-PARA TYROSINE OR RESERPINE. DOPAMINE (DA) WAS NOT DETECTED IN VENTRICULAR FLUID EITHER BEFORE OR AFTER YOHIMBINE ADMINISTRATION. YOHIMBINE ADMINISTRATION DID, HOWEVER, INCREASE INTRACELLULAR DA LEVELS IN THE CORPUS STRIATUM. THESE FINDINGS INDICATED THAT YOHIMBINE PROMOTES NE AND DA RELEASE IN THE BRAIN AND SUGGEST THAT IT ALSO MODIFIES THE ACTIVITY OF THE SEROTONIN SYSTEM. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |