Experiment 488444

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismEmpty organism
CitationKOECHEL,DA: KREJCI,ME:. (1993). EXTRARENAL AND DIRECT RENAL ACTIONS OF ATRACTYLOSIDE CONTRIBUTE TO ITS ACUTE NEPHROTOXICITY IN PENTOBARBITAL-ANESTHETIZED DOGS.. 79(1)
Amount utilized
Compound isolated
DiseaseACUTE EXTRARENAL AND RENAL CHANGES WERE NOTED. SEVERE HYPOGLYCEMIA, RESPIRATORY DEPRESSION AND HYPOXEMIA DEVELOPED WITHIN 2 HRS. IN RENAL FUNCTION, ULTRASTRUCTURAL DAMAGE TO 51, S2, S3, CELLS OF THE PROXIMAL TUBULE AND TO THICK ASCENDING LIMB CELLS AND AN IMPARED ABILITY OF THE KIDNEYS TO RESPOND TO A KNOWN DIURETIC ETHACYNIC ACID.
Dose amount32.40 MICROMOLS
Number1
Qualitative resultACTIVE
AnimalDOG
Per unitKG
Dose expressionCONC USED