Experiment 488587
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INJECTION |
| Organism | Empty organism |
| Citation | ARCOT,SS: LIPKE,DW: GILLESPIE,MN: OLSON,JW:. (1993). ALTERATIONS OF GROWTH FACTOR TRANSCRIPTS IN RAT LUNGS DURING DEVELOPMENT OF MONOCROTALINE-INDUCED PULMONARY HYPERTENSION.. 46(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | TGF-BETA-1, BETA-2 MRNA TRANSCRIPTS WERE SEEN TO BE ELEVATED BY 65%, 42% AND 61% RESPECTIVELY. TGF-ALPHA AND PDGF-A MKNA REMAINED UNCHANGED. TRANSCRIPTS FOR PDGF-B AND ET MRNA WERE INCREASED BY 32% AND 23% RESPECTIVELY IN THE EARLY STAGES BUT DECLINED TO LESS THAN CONROLS BY 34% IN THE LATTER STAGES OF MONOCROTALLIN-INDUCED HYPERTENSION. |
| Dose amount | 60.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |