Experiment 489433

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

WORTMANNIN

Details

PropertyValue
Pharmacology
INOSITOL PHOSPHATE FORMATION INHIBITION
OrganismEmpty organism
CitationNAKANISHI,S: CATT,KJ: BALLA,T:. (1994). INHIBITION OF AGONIST-STIMULATED INOSITOL 1,4,5-TRIPHOSPHATE PRODUCTION AND CALCIUM SIGNALING BY THE MYOSIN LIGHT CHAIN KINASE INHIBITOR, WORTMANNIN.. 269(9)
Amount utilized
Compound isolated
DiseaseCMPD INHIBITED SUSTAINED PHASE OF ANGIOTENSIN II-INDUCED ELEVATION OF INOSITOL 1,4,5-TRIPHOSPHATE AND INTRACELLULAR CA2+, THE LATTER EFFECT BEING SECONDARY TO FORMER.
Dose amount10.0 MICROMOLS
Number1
Qualitative resultACTIVE
AnimalCELL CULTURE
Dose expressionCONC USED