Experiment 490247
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | GOSS,PE: BAPTISTE,J: FERNANDES,B: BAKER,M: DENNIS,JW:. (1994). A PHASE I STUDY OF SWAINSONINE IN PATIENTS WITH ADVANCED MALIGNANCIES.. 54(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY 19 PATIENTS WITH BOTH SOLID TUMOR AND HEMATOLOGICAL MALIGNANCIES WERE TREATED WITH DOSES OF 50-550 MCG/KG/DAY. SIDE EFFECTS INCLUSED EDEMA, LIVER DYSFUNCTION, ELEVATED SERUM AMYLASE AND DECREASED SERUM RETINOL. DOSE LIMITING TOXICITY WAS HEPATOTOXICITY. CLEARANCE AND SERUM HALF-LIFE AND 0.5 DAY RESPECTIVELY. ONE PATIENT WITH HEAD AND NECK CANCER SHOWED >50% SHRINKAGE OF TUMOR MASS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |