Experiment 490280

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationHUIZING,MT: KEUNG,ACF: ROSING,H: VAN DER KUJI,V: TEN BOKKEL HUININK,WW: MANDES,IM: DUBBELMAN,AC: PINEDO,HM: BEIJNEN,JH:. (1993). PHARMACOKINETICS OF PACLITAXEL AND METABOLITES IN A RANDOMIZED COMPARATIVE STUDY IN PLATINUM-PRETREATED OVARIAN CANCER PATIENTS.. 11(11)
Amount utilized
Compound isolated
DiseaseIN THIS PHASE I STUDY 18 PATIENTS WITH PLATINUM PRETREATED OVARIAN CANCER WERE TREATED WITH 135-175 MG.SQ.M. ON A 3 OR 24 HOUR INFUSION SCHEDULE. GRADE 3 NEUTROPENIA OCCURED IN ALL 4 TREATMENT ARMS. ALPHA, BETA AND GAMMA HALF-LIVES WERE 0.19,1.9, AND 20.7 HOURS RESPECTIVELY OF THE 11 MEASURED FOUND 3 WERE TAXANES.
Dose amountVAR
Number1
Qualitative result.
AnimalHUMAN ADULT
Dose expressionDOSE