Experiment 490343
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | HAAS,NB: LACRETA,FP: WALCZAK,J: HUDES,GR: BRENNAN,JM: OZOLS,RF: O'DWYER,PJ:. (1994). PHASE I/PHARMACOKINETIC STUDY OF TOPOTECAN BY 24-HOUR CONTINUOUS INFUSION WEEKLY.. 54(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY 32 PATIENTS WITH MALIGNANT SOLID TUMOR WERE TREATED WITH DOSES OF 1.0-2.0 MG/SQ.M. DOSE LIMITING TOXICITY WAS NEUTROPENIA. ONE PATIENT WITH METASTATIC COLON CANCER HAD PARTIAL RESPONSE. MEAN PLASMA STEADY-STATE CONCENTRATION WAS 4.7-11.4 NM. PLASMA HALF-LIFE WAS 3.5 HOURS. MEAN TOTAL BODY CLEARANCE WAS 388 ML/MIN/SQ.M. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |