Experiment 490526
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | LI,CG: LI,GH: LIU,XQ: CHEN,HN: LI,CY:. (1989). HISTOPATHOLOGICAL OBSERVATION ON THE TREATMENT OF ALLERGIC ENCEPHALOMYLETITIS WITH TRIPTERYGIUM WILFORDII.. 9(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | GUINEA-PIGS WITH EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS WERE GIVEN <LEIGONGTENG DECOCTION> COMPOSED OF TRIPTERYGIUM WILDORDII 6 G/KG PO ONCE DAILY. IT WAS FOUND THAT THE INFLAMMATORY REACTION, NEURAXIAL SWELLING. NEURONAL NECROSIS AND NEUROFIBRILLAR DEMYELINATING IN THE TREATMENT GROUP WAS LESS THAN THAT OF THE CONTROL GROUP GIVEN SUGAR-SALT SOLUTION. THE SPINAL CORD CROSS SECTIONAL T-LYMPHOCYTE COUNT IN THE TREATMENT GROUP WAS ALSO LESS THAN THAT OF THE CONTROL GROUP (P<0.005), INDICATING THAT THE DRUG COULD INHIBIT T-LYMPHOCYTE INFILTRATION, HENCE SUPPRESSING IMMUNOLOGICAL RESPONSE OF CELLS IN THE CNS AND ALLEVIATING TISSUE DAMAGE. |
| Dose amount | 6.0 GM |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | GUINEA PIG |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | DECOCTION |