Experiment 490540

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismTripterygium wilfordii (CELASTRACEAE)
CitationYANG,L:. (1989). TREATMENT OF 43 CASES OF REFRACTORY KIDNEY DISEASES WITH TRIPTERYGIUM WILFORDII GLYCOSIDES PLUS YISHEN HUAYU DECOCTION.. 24(9)
Amount utilized
Compound isolated
Disease15 CASES OF NEPHROTIC NEPHRITIS AND 28 CASES OF PRIMARY GLOMERULONEPHRITIS (21 RESISTANT TO STEROIDS, 7-DEPTNDENT ON STEROIDS, 15 READILY RELAPSE CASES) WERE TREATED WITH THE TOTAL GLYCOSIDE OF TRIPTERYGIUM WILFORDII <LEIGONGTENG> PLUS <YISHEN HUAYU DECOCTION> COMPOSED OF THE RHIZOME OF REHMANNIA GLUTINOSA <SHENGDI>, FRUIT OF LYCIUS BARBARUS <GOUQI>, PROCESSED ROOT TUBER OF POLYGONUM MULTIFLORUM <ZHISHOUWU>, TUBER OF DIOSCOREA OPPOSITA <HUAISHANYAO>, ROOT OF ASTRAGALUS MEMBRANACEUS <HUANGQI>, AERIAL PART OF LYCOPUS LUCIDUS <ZELAN>, GRAIN OF COIX LACHRYMA-JOBI <YIYIREN>, ROOT OF SALVIA MILTIORRHIZA <DANSHEN>,WHOLE PLANT OF CYNANCHUM PANICULATUM <KUCHANGQING>, LEECH <SHUIZI>, AND LICORICE <GANCAO>. THE SEED OF PLANTAGO ASIATICA <CHEQIANZI> AND SCLEROTIUM OF POLYPORUS UMBELLATUS <ZHULING> WERE ADDED FOR SEVERE EDEMA OF THE LOWER LIMBS. THE BARK OF EUCOMMIA ULMOIDES <DUZHONG> AND ROOT OF ACHYRANTHES BIDENTATA <NIUXI> WERE PRESCRIBED FOR SEVERE LUMBER PAIN. AMBER <HUPO> AND RHIZOME OF RUBIA CORDIFOLIA <QIANCAO> WERE GIVEN FOR PATIENTS WITH HEMATURIA. THE ROOT OF MORINDA OFFICINALIS <BAJITIAN> AND RHIZOME OF CURCULIGO ORCHIOIDES <XIANMAO> WERE ADDITIONALLY PRESCRIBED FOR PATIENTS WITH YANG ASTHENIA AND AVERSION TO COLD. THE INITIAL DOSAGE OF THE TOTAL GLYCOSIDE WAS 1-1.5 MG/KG/DAY IN 3 DOSES AFTER MEALS. THE DOSE AFTER SUPPER WAS OMITTED 2 WEEKS AFTER DISAPPEARANCE OF PROTEINORIA. AFTER 2 MORE WEEKS, THE DOSE AFTER LUNCH WAS ALSO OMITTED AND THE DOSE AFTER BREAKFAST MAINTAINED FOR 8 WEEKS. THE DECOCTION (LEECH NOT DECOCTED) WAS ADMINISTERED TWICE DAILY UNITL 4 WEEKS AFTER DISAPPEARANCE OF PROTEINURIA. THEN THE DECOCTION INGREDIENTS WERE GIVEN AS A HONEY PILL AT 50 G TWICE DAILY. THERE WERE 21 CASES CONTROLLED (PROTEINURIA NEGATIVE, SIGNS AND SYMPTOMS DISAPPEARED) AND 17 CASES IMPROVED (PROTEIN IN 24 HURINE REDUCED BY 50%, SIGNS AND SYMPTOMS IMPROVED), THE TOTAL EFFECTIVE RATE BEING 88.4%. PROTEINURIA BECAME NEGATIVE IN 8-140 DAYS. ONE TYPICAL CASE WAS PRESENTED.
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractCHROMATOGRAPHIC FRACTION