Experiment 491326

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVO

Compounds isolated

TAXOL

Details

PropertyValue
Pharmacology
PHARMACOKINETIC STUDY OF
Administration routeINTRACRANIAL
OrganismEmpty organism
CitationWALTER,K: CAHAN,M: GUR,A: TYLER,B: HILTON,J: COLVIN,O: BURGER,P: DOMB,A: BREM,H:. (1994). INTERSTITIAL TAXOL DELIVERED FROM A BIODEGRADABLE POLYMER IMPLANT AGAINST EXPERIMENTAL MALIGNANT GLIOMA.. 54(8)
Amount utilized
Compound isolated
DiseaseTAXOL INCORPORATED INTO A BIODEGRADABLE POLYANHYDRIDE MATRIX FOR TREATMENT OF MALIGNANT GLIOMA MAINTAINED A CONCENTRATION OF 75-125 NG/MG OF BRAIN TISSUE 30 DAYS POST-IMPLANT WITHIN A 1-3 MM RADIUS OF THE DISC. AT POINTS MORE DISTANT, UP TO 8 MM, CONCENTRATION WAS GREATER THAN 4 NG TAXOL/MG OF BRAIN TISSUE.
Dose amount2.0 MG
Number2
Qualitative resultACTIVE
AnimalRAT
Per unitANIMAL
Dose expressionDOSE