| Disease | THE PRESENT STUDY REPORTED THE EFFECT OF 2 MALE ANTIFERTILITY AGENTS GOSSYPOL ACETIC ACID AND GTW ON DNA OF C3H10T1/2 MOUSE FIBROBLASTS. THESE RESULTS SHOWED THAT CELLS TREATED WITH GOSSYPOL OR GTW AT HIGH CONCNS. (2-3 NG/ML) FOR 4 H, SHOWED
SILVER GRAINS IN THEIR NUCLEI AS MUCH AS DID THE CELLS TREATED WITH N-ME N'-NITRO-N-NITROAOGUANIDINE, A KNOWN CARCINOGEN. HOWEVER, IF THE AGENTS WERE USED AT MODERATE CONCNS. (O.5-1 NG/ML), THE SILVER GRAINS WERE MUCH LESS; IF THE CONCNS. OF
GOSSYPOL OR GTW WERE O.1-0.3 NG/ML, THE SILVER GRAINS WERE THE SAME AS THE CONTROL GROUP. IN A COLONY-FORMING TEST, THE CELL LOST THEIR PROLIFERATING ABILITY, SINCE NO COLONIES FORMED IF GOSSYPOL OF GTW WERE AT HIGH CONCNS.: HOWEVER, AT
MODERATE OR LOW CONCNS., THE COLONY-FORMING RATE WAS HIGH AS 8.1-10.5%. TAKING ALL OF THESE RESULTS INTO CONSIDERATION, THE AUTHORS SUGGESTED THAT HIGH CONCNS. OF GOSSYPOL OR GTW CAN DAMAGE CELL DNA SEVERELY; MODERATE CONCNS. OF THE AGENTS
BREAK CELL DNA TO CERTAIN EXTENT, BUT THE CELLS CAN REPAIR, AND LOW CONCNS. OF GOSSYPOL OR GTW EXERT NO OBVIOUS EFFECT ON CELLS. |