Experiment 493864

Compounds isolated

Details

PropertyValue
Pharmacology
OrganismDendroaspis angusticeps (ELAPIDAE)
CitationSCHWEITZ,H: HEURTEAUX,C: BOIS,P: MOINIER,D: ROMEY,G: LAZDUNSKI,M:. (1994). CALCICLUDINE, A VENOM PEPTIDE OF THE KUNITZ-TYPE PROTEASE INHIBITOR FAMILY, IS A POTENT BLOCKER OF HIGH-THRESHOLD CA(2+) CHANNELS WITH A HIGH AFFINITY FOR L-TYPE CHANNELS IN CEREBELLAR GRANULE NEURONS.. 91(3)
Amount utilized
Compound isolated
DiseaseLABELED CMPD BINDS TO OLFACTORY BULB, MOLECULAR LAYER OF DENTATE GYRUS, STRATUM ORIENS OF CA3 FIELD OF HIPPOCAMPAL FORMATION, AND GRANULAR LAYER OF CEREBELLUM. BLOCKS L-SUBTYPE NEURONAL CA(2+) CHANNELS.
Dose amount5.0 NANOMOLS
Number2
Qualitative resultACTIVE
AnimalRAT
Dose expressionCD90