Experiment 493896
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRACEREBRAL |
| Organism | Empty organism |
| Citation | BEAL,M: BROUILLET,E: JENKINS,B: FERRANTE,R: KOWALL,N: MILLER,J: STOREY,E: SRIVASTAVA,R: ROSEN,B: HYMAN,B:. (1993). NEUROCHEMICAL AND HISTOLOGIC CHARACTERIZATION OF ATRIATAL EXCITOTOXIC LESIONS PRODUCED BY THE MITOCHONDRIAL TOXIN 3-NITROPROPIONIC ACID.. 13(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | CMPD PRODUCED STRIATAL LESION. ASPINY AND SPINEY NEURONS EQUALLY AFFECTED. NMDA ANTAGONIST MK801 HAD NO PROTECTIVE EFFECT. EFFECT BLOCKED BY DECORTICATION. CHRONIC ADMINISTRATION RESULTED IN PREFERENTIAL SPARING OF NADPH-DIAPHORASE INTERNEURONS, AND CHANGES IN SPINY NEURONS SIMILAR TO THOSE SEEN IN HUNTINGON'S DISEASE |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |