Experiment 496688
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Avena sativa (POACEAE) |
| Citation | BRAATEN,J: SCOTT,F: WOOD,P: RIEDEL,K: WOLYNETZ,M: BRULE,D: COLLINS,M:. (1994). HIGH BETA-GLUCAN OAT BRAN AND OAT GUM REDUCE POSTPRANDIAL BLOOD GLUCOSE AND INSULIN IN SUBJECTS WITH AND WITHOUT TYPE 2 DIABETES.. 11(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE AIM OF THE CURRENT STUDY WAS TO CHARACTERIZE THE EFFECTS OF ISOLATED AND NATIVE SOURCES OF BETA-GLUCAN, OAT GUM AND OAT BRAN, RESPECTIVELY, WHEN INCORPORATED INTO A COMPLETE MEAL. FASTING CONTROL SUBJECTS AND SUBJECTS WITH TYPE 2 DIABETES WERE FED PORRIDGE MEALS CONTAINING EITHER WHEAT FARINA, WHEAT FARINA PLUS OAT GUM OR OAT BRAN. BLOOD SAMPLES WERE COLLECTED FOR 3 H AFTER THE TEST MEALS AND PLASMA GLUCOSE AND INSULIN WERE MEASURED. OAT BRAN AND WHEAT FARINA PLUS OAT GUM MEALS REDUCED THE POSTPRANDIAL PLASMA GLUCOS EXCURSIONS AND INSULIN LEVELS WHEN COMPARED WITH THE CONTROL WHEAT FARINA MEAL IN BOTH CONTROL AND TYPE 2 DIABETIC SUBJECTS. THIS STUDY SHOWS THAT BOTH THE NATIVE CELL WALL FIBRE OF OAT BRAN AND ISOLATED OAT GUM, WHEN INCORPORATED INTO A MEAL, ACT SIMILARLY BY LOWERING POSTPRANDIAL PLASMA GLUCOSE AND INSULIN LEVELS. A DIET RICH IN BETA-GLUCAN MAY THEREFORE BE OF BENEFIT IN THE REGULATION OF POSTPRANDIAL PLASMA GLUCOSE LEVELS IN SUBJECTS WITH TYPE 2 DIABETES. |
| Dose amount | 66.5 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | BRAN |
| Gender | GIVEN TO BOTH SEXES |