Experiment 49697
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Karwinskia humboldtiana (RHAMNACEAE) |
| Citation | IZQUIERDO,AE: NIETO,D:. (1965). NEUROPATHOLOGICAL ASPECTS OF INTOXICATION WITH KARWINSKIA HUMBOLDTIANA STUDIED IN EXPERIMENTAL ANIMALS.. 95() |
| Amount utilized | |
| Compound isolated | |
| Disease | A SINGLE DOSE OF FINELY GROUND ENDOCARP OF THE DRUPE (FRUIT) WAS GIVEN TO SIX ALBINO RATS. SIX TO EIGHT DAYS LATER THE ANIMALS SHOWED SIGNS OF FLACCID PARALYSIS OF THE HIND LIMBS, WHICH RAPIDLY EXTENDED TO THE ANTERIOR LIMBS. SIGNS OF BULBAR INVOLVEMENT DEVELOPED IN THE MOST SEVERELY AFFECTED ANIMALS. TWO OF THE ANIMALS WERE SACRIFICED WHEN THE PARALYSIS WAS LIMITED TO THE HIND LIMBS AND THE AFFECTED TISSUES WERE EXAMINED MICROSCOPICALLY. DATA ARE PRESENTED CONCERNING THE NEUROTOXIC HISTOLOGICAL FINDINGS (INCLUDING PHOTOMICROGRAPHS). |
| Dose amount | 1.0 GM |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Extract | FRUIT |