Experiment 497987
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Empty organism |
| Citation | ALONSO-AMELOT,M: CASTILLO,U: DE JONGH,F:. (1993). PASSAGE OF THE BRACKEN FERN CARCINOGEN PTAQUILOSIDE INTO BOVINE MILK.. 73(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | PTAQUILOSIDE HAS BEEN DISCOVERED FOR THE FIRST TIME IN MILK SAMPLES OF A BOVINE FED A DIETARY COMPLEMENT (6 KG FRESH WEIGHT/DAY) OF FRESHLY CUT BRACKEN FRONDS. THIS WAS EQUIVALENT TO CA 216 MG/DAY PURE PTAQUILOSIDE. THE COMPOUND WAS FOUND IN A QUANTITY OF NO LESS THAN 0.11 MG/L IN MILK. THIS WAS DETERMINED BY THE APPEARANCE OF PTEROSIN B - THE DECOMPOSITION PRODUCT OF PTAQUILOSIDE - IN PREPURIFIED MILK SAMPLES TREATED WITH MILD ALKALI (PH 8.0 AND 11.5). THE LACK OF BASE TREATMENT LED TO THE ABSENCE OF PTEROSIN B. A MILK PREPURIFICATION PROTOCOL BASED ON METHANOL-ACETONITRILE PRECIPITATIONS IN SUCCESSION, HEXANE AND DICHLOROMETHANE EXTRACTIONS, ALKALINE TREATMENT, REEXTRACTION AND SILICA GEL MICROCOLUMN CHROMATOGRAPHY FOLLOWED BY REVERSE-PHASE HPLC WAS DEVELOPED FOR THE DETECTION OF PTAQUILOSIDE. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | COW |
| Dose expression | DOSE |