Experiment 505228

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationBROSCHARD,TH: WIESSLER,M: VON DER LIETH,CW: SCHMEISER,HH:. (1994). TRANSLESIONAL SYNTHESIS ON DNA TEMPLATES CONTAINING SITE-SPECIFICALLY PLACED DEOXYADENOSINE AND DEOXYGUANOSINE ADDUCTS FORMED BY THE PLANT CARCINOGEN ARISTOLOCHIC ACID.. 15(10)
Amount utilized
Compound isolated
DiseaseCMPD FORMS ADDUCT IN SYNTHETIC OLIGONUCLEOTIDES WITH DEOXYADENINE OR DEOXYGUANINE RESIDUES, WHICH CAN BE SUBSEQUENTLY TRANSCRIBED ALLOWING INCORPORATION OF D-TMP AND D-AMP EQUALLY AND DCMP RESPECTIVELY. THE FORMER LESION EITHER BLOCKS REPLICATION OR ALLOWS TRANSVERSION MUTATION.
Dose amount2.0 MILLIMOLS
Number1
Qualitative resultACTIVE
Dose expressionCONC USED