Experiment 505440
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | CROSS,DAE: ALESSI,DR: VANDENHEEDE,JR: MC DOWELL,HE: HUNDAL,HS: COHEN,P:. (1994). THE INHIBITION OF GLYCOGEN SYNTHASE KINASE-3 BY INSULIN OR INSULIN-LIKE GROWTH FACTOR 1 IN THE RAT SKELETAL MUSCLE CELL LINE L6 IS BLOCKED BY WORTMANNIN, BUT NOT BY RAPAMYCIN: EVIDENCE THAT WORTMANNIN BLOCKS ACTIVATION OF THE MITOGEN-ACTIVATED. 303(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | CMPD PREVENTED ACTIVATION OF EITHER MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-1BETA(MAPKAP KINASE-1BETA) RO P70S6 KINASE BY INSULIN OR INSULIN-LIKE GROWTH FACTO-1(IGF-1). THIS IN TURN INHIBITED INACTIVATION OF GLYCOGEN SYNTHASE KINASE-3 BY ONE OF THESE ENZYMES. ASSAYED IN L6 CELL CULTURE. |
| Dose amount | 100.0 NANOMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | CONC USED |