Experiment 508760
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | WHITEHOUSE,MW: FAIRLIE,DP: THONG,YH:. (1994). ANTI-INFLAMMATORY ACTIVITY OF THE ISOQUINOLINE ALKALOID, TETRANDRINE, AGAINST ESTABLISHED ADJUVANT ARTHRITIS IN RATS.. 42(3/4) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THE ADJUVANT-INDUCED POLYARTHRITIS, TETRANDINE WAS NOT EFFECTIVE WHEN GIVEN AT THE TIME OF INOCULATION(DAY0), NOR JUST BEFORE(DAY7-10) SIGNS OF ARTHRITIS WERE EVIDENT. HOWEVER, WHEN GIVEN ON A THERAPEUTIC DOSE SCHEDULE(DAYS10-13) OR CONTINUALLY (DAY-1 TO +14) ON A PROPHYLACTIC SCHEDULE, SIGNS OF ARTHRITIS INCLUDING WEIGHT LOSS DUE TO CACHEXIA WERE SIGNIFICANTLY REDUCED. |
| Dose amount | 80.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |