Experiment 509459
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | XU,Y: GU,ZP: TONG,JS: WANG,Y: ZHANG,ZT: LIN,N: QIAN,SZ:. (1993). THE EFFECT OF COMBINED USED OF GOSSYPOL AND TESTOSTERONE UNDECANOATE ON THE FERTILITY OF MALE RATS.. 13(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | STUDIES WERE UNDERTAKEN TO ASSESS THE EFFECT OF THE SEQUENTIAL USE OF TESTOSTERONE UNDECANOATE (TU) AND GOSSYPOL (G) ON THE FERTILITY OF MALE RATS. IN MALE RATS, TU WS GIVEN AT A DOSE OF 12 MG/KG EVERY 2-4 WK, 3 TIMES. ALL THE TREATED RATS BECAME INFERTILE WITH A DECREASE IN BOTH THE DENSITY AND MOTILITY OF EPIDIDYMAL SPERMATOZOA. THEN G WAS GIVEN BY GASTRIC GAVAGE AT A DOSE OF 12 MG/KG PER DAY, 6 TIMES A WEEK FOR 3 MOS. THE TREATED RATS REMAINED INFERTILE. THE FERTILITY OF THE TREATED RATS BEGAN TO RECOVER 3 WKS AFTER WITHDRAWL OF G AND WAS FULLY RESTORED 2 WKS LATER. RESULTS INDICATE THAT SUBSTITUTION OF TU FOR THE LOADING DOSE OF G MAY PROVIDE A POTENTIAL APPROACH TO THE ALLEVIATION OF SIDE EFFECTS OF BOTH DRUGS. |
| Dose amount | 12.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |