Experiment 511617
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | THORBURN,J: THORBURN,A:. (1994). THE TYROSINE KINASE INHIBITOR, GENISTEIN, PREVENTS ALPHA-ADRENERGIC-INDUCED CARDIAC MUSCLE CELL HYPERTROPHY BY INHIBITING ACTIVATION OF THE RAS-MAP KINASE SIGNALING PATHWAY.. 202(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | GENISTEIN TREATMENT PREVENTS PHENYLEPHRINE-INDUCED ACTIVATION OF THREE PROMOTERS (FOS, ATRIAL NATRIURETIC FACTOR, ANF, AND THE MYOSIN LIGHT CHAIN 2, MLC-2), WHICH ARE ACTIVATED IN THE HYPERTROPHIC RESPONSE. GENISTEIN ALSO INHIBITS PHENYLEPHRINE-INDUCED ACTIVATION OF THE MITOGEN ACTIVATED PROTEIN (MAP) KINASES ERK1 AND ERK2 AND INHIBITS GTP LOADING FO THE RAS PROTEIN. |
| Dose amount | 70.0 MICROMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Dose expression | CONC USED |