Experiment 521844
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | GALELLI,A: DELCOURT,M: WAGNER,MC: PEUMANS,W: TRUFFA-BACHI,P:. (1995). SELECTIVE EXPANSION FOLLOWED BY PROFOUND DELETION MATURE V-BETA-8.3+ T CELLS IN VIVO AFTER EXPOSURE TO THE SUPERANTIGENIC LECTIN URTICA DIOICA AGGLUTININ.. 154(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | DOSING COMPOUND RESULTS IN THE FOLLOWING SEQUENCE: AFTER 2 DAYS, PROPORTION OF V-BETA-8.3+ T CELLS (CD4 AND CD8) IN PERIPHERY INCREASED TO TWICE NORMAL, BUT CELLS ARE ANERGIC TO RESTIMULATION BY COMPOUND AND FAILED TO PRODUCE IL-2. AFTER 1 WEEK, ALL CD4 V-BETA-8.3 T CELLS HAVE BEEN DELETED THROUGH APOPTOSIS. EFFECT SEEN IN THYMECTOMIZED OR THYMUS-PRESENT ANIMALS. |
| Dose amount | 50.0 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | ANIMAL |
| Dose expression | DOSE |