Experiment 523000
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | ZHENG,J: FANG,J: GAO,J: GUO,HZ: XU,LF: YENG,YP: YU,ZH: SUN,HZ:. (1986). EFFECTS OF THE TOTAL GLYCOSIDES OF TRIPTERYGIUM WILFORDII ON THE REPRODUCTIVE ORGANS OF EXPERIMENTAL ANIMALS. III. DYNAMIC OBSERVATION ON THE REPRODUCTIVE ORGANS AND FERTILITY IN MICE.. 8(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TOTAL GLYCOSIDES OF T. WILFORDII, GIVEN ORALLY AT 30 MG/KG/DAY FOR 1-3 MO TO MICE, HAD A DEFINITE AND REVERSIBLE ANTIFERTILE ACTION IN MALE ANIMALS; CHANGES IN THE TESTIS AND THE NO. OF THE SPERMATOZOA WERE NOTED. HOWEVER, IT DID NOT AFFECT THE REPRODUCTIVE ORGANS AND FERTILITY OF FEMALE ANIMALS AND THE REPRODUCTIVE ORGANS OF THE 1ST 3 GENERATIONS OF THEIR MALE OFFSPRINGS; IRREGULAR ESTROUS CYCLES WERE OBSD. IN THE FEMALE ANIMALS. THE REPRODUCTIVE TOXICITY OF THE GLYCOSIDES WAS HIGHER IN RATS THAN IN MICE. |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | CHROMATOGRAPHIC FRACTION |
| Gender | MALE |