Experiment 523005
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Tripterygium wilfordii (CELASTRACEAE) |
| Citation | SUNG,XO: FANG,YH: HUANG,GZ:. (1989). TOXICITY OF THE ALKALOIDS OF TRIPTERYGIUM WILFORDII HOOK ON RAT TESTIS.. 9(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | STUDIES WERE UNDERTAKEN TO ASSESS THE EFFECTS OF THE TOTAL ALKALOIDS EXTD. FROM T. WILFORDII (ATW) A KIND OF CHINESE HERB MEDICINE, ON FERTILITY OF MALE RATS. ATW WAS GIVEN BY GATRIC GAVAGE WITH A SINGLE DOSE, AT 500-1500 MG/KG. THE RESULTS SHOW THE ATW CAN CAUSE DAMAGE OF SEMINIFEROUS EPIDERMIS CELLS OF TESTIS AND SPERMATOGONIA ARE PRESENT. ALL OTHER PARAMETERS EXAMD. INCLUDING THE SERUM TESTOSTERONE LEVEL AND THE HISTOL. OF VARIOUS ORGANS AND TISSUES, ARE NORMAL. THE RESULTS SUGGEST THAT ATW HAS AN ANTISPERMATOGENIC ACTION SIMILAR TO THAT OF GOSSYPOL. |
| Dose amount | 500.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | TOTAL ALKALOIDS |
| Gender | MALE |