Experiment 53332
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Gelsemium sempervirens (LOGANIACEAE) |
| Citation | JEPSON,E:. (1986). POISONING BY GELSEMIUM SEMPERVIRENS.. 189() |
| Amount utilized | |
| Compound isolated | |
| Disease | AN ADVERSE REACTION DUE TO TREATMENT WITH GELSEMIUM SEMPERVIRENS IS DESCRIBED. THE PATIENT WAS BEING TREATED FOR VERY SEVERE NEURALGIA AROUND THE TEMPLES. A DOSE OF 10 MINS WITH A BISMUTH MIXTURE WAS TAKEN EVERY 2 TO 3 HOURS. THE PAIN WORSENED TO THE POINT OF BEING INTOLERABLE TO THE PATIENT, SO 20 MINS WAS ADMINISTERED EVERY THREE HOURS. THREE OR FOUR OF THESE DOSES WERE TAKEN DURING THE NIGHT. THE PATIENT WOKE AT 8 AM FEELING SOME RELIEF. HOWEVER AT 9:00 A.M., THE PATIENTS CONDITION WORSENED. THE PATIENT LOST THE ABILITY TO MOVE HER TONGUE, INCLUDING LOSS OF SPEECH AND GREAT DIFFICULTY SWALLOWING. HER PUPILS WERE DILATED AND HER VISION BLURRED. THE PATIENT LOST COORDINATION AND MOVEMENT IN HER HANDS AND ARMS SO SHE COULD NO LONGER WRITE HER NAME. THE PATIENT REMAINED CONSCIOUS AND WAS ABLE TO ANSWER QUESTIONS BY NODDING HER HEAD. IN ORDER TO AVERT FURTHER PARALYSIS, ONE MIN OF STRYCHNINE WAS ADMINISTERED SUBCUTANENOUSLY. MARKED IMPROVEMENT WAS SEEN WITHIN 10 MINS, AND THE CONDITION FURTHER IMPROVED WHEN THE PATIENT WAS ABLE TO TAKE FOOD AND STIMULANTS. THOUGH PARALYSIS DISAPPEARED AT THIS POINT, IT TOOK SEVERAL HOURS BEFORE VISION WAS COMPLETELY RESTORED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | TINCTURE |
| Gender | FEMALE |