Experiment 537962
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IM |
| Organism | Empty organism |
| Citation | ZWEYGARTH,E: SCHILLINGER,D: KAUFMANN,W: ROTTCHER,D:. (1986). EVALUATION OF SINEFUNGIN FOR THE TREATMENT OF TRYPANOSOMA (NANNOMONAS) CONGOLENSE INFECTIONS IN GOATS.. 37(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | SINGLE DOSES FROM 10 TO 20 MG/KG BODYWEIGHT GIVEN INTRAMUSCULARLY WERE NOT CURATIVE FOR GOATS; SINGLE DOSES OF 25 AND 50 MG/KG WERE TOXIC, AND CAUSED DEATH. FIVE AND 7.5 MG/KG ADMINISTRATERED TWICE DAILY OVER A THREE-DAY PERIOD, RESULTED IN A CURE IN 2 ANIMALS, WHILE 2 OTHERS RELAPSED. ALL ANIMALS RELAPSED WHEN GIVEN A SINGLE DAILY DOSE OF 5 OR 7.5 MG/KG FOR 4 CONSECUTIVE DAYS. WHEN SUCH DOSES WERE GIVEN TWICE A DAY, THEY CAUSED DEATH IN 50% OF THE GOATS AND THE REMAINDER WERE CURED. RAISED SERUM UREA LEVELS INDICATED THE SERVERE NEPHROTOXIC SIDE-EFFECTS OF SINEFUNGIN EVEN AT SUBCURATIVE LEVELS. HISTOPATHOLOGICAL EXAMINATIONS REVEALED AN ACUTE TUBULONEPHROSIS. |
| Dose amount | 7.5 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | GOAT |
| Per unit | KG |
| Dose expression | DOSE |