Experiment 538717
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | KATO,M: PU,MY: ISOBE,KI: IWAMOTO,T: NAGASE,F: LWIN,T: ZHANG,YH: HATTORI,T: YANAGITA,N: NAKASHIMA,I:. (1994). CHARACTERIZATION OF THE IMMUNOREGULATORY ACTION OF SAIKOSAPONIN-D.. 159(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | SSD DISPLAYED A DEFINITE ACTION IN VITRO TO BIDIRECTIONALLY CONTROL THE GROWTH RESPONSE OF T LYMPHOCYTES STIMULATED BY CON A, ANTI-CD3 MONOCLONAL ANTIBODY, AND CALCIUM INOPHORE A23187 PLUS PHORBOL 12-MYRISTATE 13-ACETATE. LOW CONCNS. (1-3UG/ML) OF SSD UPREGULATED THE RESPONSES TO SUBOPTIMUM STIMULI, PARTICULARY DURING THE RELATIVELY LATE STGE OF THE RESPONSES, WHERAS IT DOWNREGULATED THE RESPONSES TO SUPROAPTIMAL STIMULI. UNDER APPROPRIATE EXPTL. CONDITIONS, SSD PROMOTED INTERLUKIN-2 (IL-2) PRODN. AND IL-2 RECEPTOR EXPRESSION. IT ALSO ACCELERATED C-FOS GENE TRANSCRIPTION, BUT IT DID NOT MODULATE THE LEVEL OF TYROSINE PHOSPHORYLATION OF CELLULAR PROTEINS. |
| Dose amount | 1.0 MCG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Per unit | ML |
| Dose expression | CONC USED |