Experiment 548379

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

CAMPTOTHECIN

Details

PropertyValue
Pharmacology
TOPOISOMERASE I(MAMMALIAN)-MEDIATED DNA CLEAVAGE INDUCTION
OrganismEmpty organism
CitationPOMMIER,Y: JENKINS,J: KOHLAGEN,G: LETEURTRE,F:. (1995). DNA RECOMBINASE ACTIVITY OF EUKARYOTIC DNA TOPOISOMERASE I; EFFECTS OF CAMPTOTHECIN AND OTHER INHIBITORS.. 337(2)
Amount utilized
Compound isolated
DiseaseCMPD INHIBITS PROPER FUNCTIONING OF TOPOISOMERASE I RELIGATION STEP RESULTING IN DNA DOUBLE-STRAND BREAKS.
Dose amount100.0 MICROMOLS
Number1
Qualitative resultACTIVE
AnimalCELL CULTURE
Dose expressionCONC USED