Experiment 549287
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Empty organism |
| Citation | YU,SG: ANDERSON,PJ: ELSON,CE:. (1995). EFFICACY OF BETA-IONONE IN THE CHEMOPREVENTION OF RAT MAMMARY CARCINOGENESIS.. 43(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | SECONDARY PRODUCTS OF PLANT MEVALONATE METABOLISM SUPPRESS THE SYNTHESIS OF MEVALONATE, THE RATE-LIMITING SUBSTRATE FOR THE SYNTHESIS OF ISOPRENOID INTERMEDIATES ESSENTIAL FOR CELL PROLIFERATION. D-LIMONENE IS AN EFFECTIVE ANTICARCINOGEN WHEN TESTED WITH CHEMICAL CARCINOGENS. THIS MONOTERPENE ALSO CAUSES THE REGRESSION OF CHEMICALLY ESTABLISHED TUMORS. GERANIOL SUPPRESSES THE GROWTH OF TRANSPLANTED TUMORS. THE POTENCY OF BETA-IONONE IN SUPPRESSING 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE (HMGR) ACTIVITY EXCEEDS THAT EITHER MONOTERPENE. IN PARALLEL TRIALS, THE EFFICACIES OF EQUIMOLAR INTAKES (36 MMOL/KG OF DIET) OF D-LIMONENE AND GERANIOL WERE COMPARED WITH THAT OF BETA-IONONE IN THE CHEMOPREVENTION OF 7,12- DIMETHYLBENZ[A]ANTHRACENE-INITATED MAMMARY CANCER. THE MONOTERPENES DECREASED TUMOR MULTIPLICITY BY 45% (P<0.001). THE IMPACT OF BETA-IONONE ON TUMOR MULTIPLICITY WAS 2X THAT OF THE MONOTERPENES (P<0.001). TUMOR INCIDENCE AND LATENCY WERE AFFECTED TOV ARYING DEGREES. THE LOCUS OF THE ACTION OF THE ISOPRENOIDS IS POSTULATED TO BE IN THE SUPPRESSION OF THE STEROL-RESISTANT HMGR ACVITIVY, WHICH IS CHARACTERISTIC OF NEOPLASTIC CELLS. DIETARY GUIDELINES ADVOCATE THE CONSUMPTION OF FRUITS, VEGETABLES, AND CEREAL GRAINS, THE MAJOR SOURCES OF DIVERSE ISOPRENOIDS. |
| Dose amount | 36.0 MILLIMOLS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | FEMALE |