Experiment 549325
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | AFANAS'EY,IB: OSTRACHOVITCH,EA:. (1995). DIFFERENT ANTIOXIDANT ACTIVITIES OF BIOFLAVONOID RUTIN IN NORMAL AND IRON-OVERLOADING RATS.. 50(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF RUTIN ON LIVER MICROSOMES, PERITONEAL MACROPHAGES, AND BLOOD NEUTROPHILS ISOLATED FROM IRON-OVERLOADING (IOL) AND NORMAL RATS WERE STUDIES. IT WAS FOUND THAT RUTIN ADMINISTRATION SHARPLY SUPPRESSED FREE RADICAL PRODUCTION IN LIVER MICROSOMES AND BY PHAGOCYTES OF IOL ANIMALS AND ONLY SLIGHLY AFFECTED THESE PROCESSES IN NORMAL RATS. THE SELECTIVE INHIBITORY EFFECT OF RUTIN UNDER PATHOLOGIC CONDITIONS INDUCED BY IRON OVERLOAD IS THOUGH TO BE DUE TO THE FORMATION OF INACTIVE IRON-COMPLEXES WHICH ARE UNABLE TO CATALYSE THE CONVERSION OF SUEPROXIDE ION INTO REACTIVE HYDROXYL RADICALS, A PROCESS RESPONSIBLE FOR THE FREE RADICAL-MEDIATED TOXIC EFFECTS OF IRON OVERLOAD. |
| Dose amount | 1.0 MILLIMOLS |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |
| Gender | MALE |