Experiment 549327
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | MC COY,KL: GAINEY,D: GABRAL,GA:. (1995). DELTA-TETRAHYDROCANNABINOL MODULATES ANTIGEN PROCESSING BY MACROPHAGES.. 273(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | DELTA-TETRAHYDROCANNABINOL (THC) EXPOSURE SUPPRESSED MULTIPLE IMMUNOL FUNCTIONS OF MACROPHAGES. THE ABILITY OF MACROPHAGES EXPOSED TO THC TO PROCESS AND PRESENT SOL. PROTEIN ANTIGENS WAS INVESTIGED BY THE STIMULATION OF ANTIGEN-SPECIFIC HELPER T CELL HYBRIDOMAS WAS DRAMATICALLY REDUCED AFTER A 24-H PRETREATMENT OF A MACROPHAGE HYBRIDOMA WITH THC. IN CONTRAST, THC EXPOSURE DID NOT ALTER THE CAPACITY OF THE MACROPHAGE HYBRIDOMA TO PROCESS CHICKEN OVALBUMIN AND AUGMENTED THEIR PRESENTING CELL FUNCTION FOR A PIGEON CYTOCHROME C RESPONSE. THC DIFFERENTIALLY MODULATES THE CAPACITY OF MACROPHAGES TO PROCESS ANTIGENS THAT IS NECESSARY FOR THE ACTIVATION OF CD4+ T CELLS. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | CONC USED |