Experiment 549404
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Empty organism |
| Citation | GEBOES,K: SPIESSENS,C: NIJS,G: DE WITTE,P:. (1993). ANTHRANOIDS AND THE MUCOSAL IMMUNE SYSTEM OF THE COLON.. 47(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | EXPERIMENTAL STUDIES INDICATES THAT LAXATIVES MAY INDUCE EPITHELIAL DAMAGE. IN ADDITION, SOME LAXATIVES INDUCED THE RELEASE OF PROSTAGLANDINS. EPITHELIAL CELL DAMAGE AND RELEASE OF PROSTAGLANDINS ARE TWO PATHWAY BY WHICH EPITHELIAL CELL PROLIFERATION COULD BE INFLUENCED. IN VIVO STUDY IN RATS WAS PERFORMED TO COMPARE THE SHORT- AND LONG-TERM EFFECT OF SENNOSIDES, BISACODYL, SODIUM PICOSULFATE AND LACTULOSE ON EPITHEELIAL CELL PROLIFERATION IN THE ILEUM AND LARGE INTESTINE. TREATMENT WITH SENNOSIDES, BISACODYL AND SODIUM PICOSULFATE DOES NOT INFLUENCE THE LI IN THE ILEUM AND INDUCES NOT STATISTICALLY SIGNIFICANT INCREASE OF THE LI WHEN THE TREATED GROUPS ARE COMPARED WITH THE CONTROL GROUP. THE PROLIFERATIVE PATTERN ALONG THE CRYPTS REMAINS UNCHANGED WITH ALL THE LAXATIVES THROUGHOUT THE STUDY. IT APPEARS THERFORE THAT 'CONTACT' LAXATIVES HAVE NO MAJOR INFLUENCE ON ILEAL AND COLONIC EPITHELIAL CELL PROLIFERATION AND SHOULD NOT BE REGARDED AS TUMOR-PROMOTING SUBSTANCES. |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | FEMALE |