Experiment 549868
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | SHELDON,R: DUFF,H: KOSHMAN,ML:. (1995). ANTIARRHYTHMIC ACTIVITY OF QUINONE IN HUMANS.. 92(1044) |
| Amount utilized | |
| Compound isolated | |
| Disease | PATIENTS UNDERWENT OPEN-LABEL, DOSE-RANGING TRIALS OF QUININE WITH DAILY DOSES OF 600, 1200 AN 1800 MG IN A TWICE-DAILY DOSING REGIMEN. IN 17 PATIENTS WITH FREQUENT SPONTANEOUS VENTRICULAR ECTOPY, ORAL QUININE SUPPRESSED ARRHYTHMIA IN 11 OF 12 PATIENTS WHO FINISHED THE STUDY AND WAS NOT TOLERATED BY 4 PATIENTS WHO FINISHED THE STUDY AND WAS NOT TOLERATED BY 4 PATIENTS, AND 1 PATIENT WITHDREW FROM THE STUDY. THE MEAN EFFECTIVE DAILY DOSAGE WAS 927 MG, THE MEAN EFFECTIVE TROUGH SERUM LEVEL WAS 11 MCG/MOL/L AND THE HALF-LIFE WAS 20(DL) 7 HOURS. IN A SECOND OPEN-LABEL, DOSE-RANGING TRIAL IN 10 PATIENTS WITH INDUCIBLE VENTRICULAR TACHYCARDIA AND REDUCED LEFT VENTRICULAR SYSTOLIC FUNCTION, QUININE SUPPRESSED INDUCIBILITY OF VENTTRCULAR TACHYCARDIA IN 3 OF 10 PATIENTS, AT A BASIC PACING CYCLE LENGTH OF 500 MILLISECONDS. VENTRICULAR EFFECTIVE REFRACTORY PERIOD WAS PROLONGED. IN THE REMAINING PATIENTS, VENTRICULAR TACHYCARDIA CYCLE LENGTH WAS PROLONGED. THE CORRECTED QT INTERVAL WAS NOT PROLONGED. QUININE IS AN EFFECTIVE AND CONVENIENT ANTIARRHYTHMIC DRUG FOR THE SUPPRESSION OF VENTRICULAR ARRHYTHMIAS IN HUMANS. |
| Dose amount | 927.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |