Experiment 549869
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | SHEPHARD,GS: THIEL,PG: SYDENHAM,EW: SAVARD,ME:. (1995). FATE OF A SINGLE DOSE OF 14-C-LABELLED FUMONISIN B1 IN VERVET MONKEYS.. 3(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE MYCOTOXIN FUMONISIN B1 (FB1) WAS DOSED AS 14-C-LABELLED FB1. EXCRETA WERE COLLECTED OVER A 24-HR PERIOD, WHEREAFTER TH MONKEYS WERE SACRIFICED AND SELECTED ORGANS AND CONTENTS OF THE GUT COLLECTED OVER 24-HR PERIOD, WHEREAFTER THE MONKEYS WERE SACRIFICED AND SELECTED ORGANS AND CONTENTS OF THE GUT COLLECTED TO DETERMINED THE DISTRIBUTION OF 14C-LABELED THE BULK OF THE RADIOACTIVITY RECOVERED FROM TISSUE WAS FOUND IN THE LIVER, WHILE A FUTHER 68.1% AND 64.0% WERE RECOVERED IN IN EXCRETA, BILE, AND THE GUT CONTENTS. ANALYSIS OF FAECES AND GUT CONTENTS SHOWED THAT RADIOACTIVITY WAS DUE TO FB1, ITS PARTIALLY HYDROLYSED METABOLITES, AND TRACE AMOUNTS OF THE FULLY HYDROLYSED AMINOPENTOL MOIETY. ANALYSIS OF BILE SHOWED AN ABSENCE OF HYDROLYSIS PRODUCTS, INDICATING THAT HYDROLYSIS OCCURRED ONLY IN THE GUT, RESULTING IN THE RMMOVAL OF THE TRICARBALLYLIC ACID MOIETY AT THE C-14-POSITION. DETERMINATION OF FB1 LEVELS IN PLASMA FOLLOWING A GAVAGE DOSE INDICATED THAT ONLY LIMITED AMOUNTS OF FB1 WERE ABSORBED. |
| Dose amount | 1.72 MG |
| Number | 1 |
| Qualitative result | . |
| Animal | MONKEY |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Gender | MALE |