Experiment 552600

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationSLEPNEVA,IA: SERGEEVA,SV: KHRAMTSOV,VV:. (1995). REVERSIBLE INHIBITION OF NADPH-CYTOCHROME P450 REDUCTASE BY ALPHA-LIPOIC ACID.. 214(3)
Amount utilized
Compound isolated
DiseaseNADP COMPLETELY PROTECTED REDUCTASE FROM THE INACTIVATION. THE MODIFICATION OF REDUCTASE WAS REVERSIBLE. THE MODIFIED ENZYME WAS PARTIALLY REACTIVATED WITH DITHIOTHREITOL AND DIHYDROLIPOIC ACID IN THE CASE WHEN CYTOCHROME C WAS A SUBSTRATE SUBSTRATE OF REDUCTASE. AGENT ALPHA-LIPOIC ACID IS AN EFFICIENT INHIBITOR OF BOTH PURIFIED AND MICROSAOMAL REDUCTASE.
Dose amount0.1 MILLIMOLS
Number1
Qualitative resultACTIVE
Dose expressionCONC USED