Experiment 552826
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | SC |
| Organism | Empty organism |
| Citation | REGISTER,B: BETHEL,MA: THOMPSON,N: WALMER,D: BLOHM,P: AYYASH,L: HUGHESJR,C:. (1995). THE EFFECT OF NEONATAL EXPOSURE TO DIETHYLSTILBESTROL, COUMESTROL, AND BETA-SITOSTEROL ON PITUITARY RESPONSIVENESS AND SEXUALLY DIMORPHIC NUCLEUS VOLUME IN THE CASTRATED ADULT RAT.. 208(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | ANIMALS CASTRATED ON DAY 21, AFTER EXPOSURE TO CMPD ON NEONATAL DAYS 1-10. LH ASSAYED IN ADULTS BASAL LH LEVELS INCREASED IN BOTH SEXES WHILE GNRH-INDUCED LH SURGE INHIBITED IN FEMALES ONLY. VOLUME OF MEDIAL PREOPTIC SEXUALLY DIMORPHIC NUCLEUS WAS UNAFFECTED BY TREATMENT. |
| Dose amount | 3.0 MCG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT(NEWBORN) |
| Per unit | ANIMAL |
| Dose expression | DOSE |
| Gender | MALE |