Experiment 565655
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | GREENWALD,RB: SHORR,RGL:. (1994). TAXOL-BASED COMPOSITIONS WITH ENHANCED BIOACTIVITY.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | TAXOL-BASED COMPNS. ARE DISCLOSED BASED ON THE FORMATION OF 7-CARBAMATES. IN CERTAIN ASPECTS OF THE INVENTION, THE COMPNS. INCLUDE POLYETHYLENE GLYCOL AND HAVE PROLONGED CIRCULATING LIVES IN MAMMALS, ARE HIGHLY WATER SOL. AND SUBSTANTIALLY NON- ANTIGENIC. METHODS OF PREPN. AND TREATMENT USING THE COMPNS. ARE ALSO DISCLOSED. 2'-ACETYL-7-PEG 5000 CARBAMATE TAXOL (I) WAS PREPD. AND TESTED AGAINST VARIOUS MALIGNANT HUMAN CELL LINES AND AGAINST DOXORUBICIN-SENSITIVE AND -RESISTANT MOUSE LYMPHOID NEOPLASMS. I WAS >600 TIMES MORE SOL. IN WATER THAN THE UNMODIFIED TAXOL. |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | CONC USED |