Experiment 566561
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Empty organism |
| Citation | MIURA,Y: KINOSHITA,Y: YAMAMOTO,Y: TAKAHASHI,K: KOYAMA,K: KINOSHITA,K:. (1994). PREPARATION OF RESORCIN DERIVATIVES AND THEIR USE AS TYROSINASE INHIBITORS FOR SKIN-LIGHTENING COSMETICS.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | RESORCIN DERIVS.L I (R1 = H, C1-9 ALKYL, ALKENYL), II (R2 - C2-9 ALKYL, ALKENYL), AND III (R3,4 = H, C1-9 ALKYL, ALKENYL) AS TYROSINASE INHIBITORS ARE CLAIMED. THESE RESORCIN DERIVS. ARE CHEM. STABLE AND THEIR TOXICITY IS LOW. ZNC12 WAS DISSOLVED IN PRCO2H AND THE SOLN. WAS TREATED WITH 110 G RESORCINOL AT 150 D FOR 20 MIN TO GIVE 2,4-DIHYDROXYETHYLPHENONE, WHICH IN AQ. HCI WAS REDUCED WITH A ZN AMALGAM TO GIVE 88 G I(R1 = E+) (IV). IC50 OF IV ON TYROSINASE WAS 2 UM. |
| Dose amount | 2.0 MICROMOLS |
| Number | 2 |
| Qualitative result | ACTIVE |
| Dose expression | IC50 |