Experiment 568793
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IM |
| Organism | Empty organism |
| Citation | POMERANTZ,SM: HEPNER,BC: WERTZ,JM:. (1994). IMPAIRMENT OF MALE COPULATORY BEHAVIOR IN RHESUS MONKEYS FOLLOWING ACUTE ADMINSITRATION OF COCAINE.. 54(13) |
| Amount utilized | |
| Compound isolated | |
| Disease | ALTHOUGH NUMEROUS STUDIES IN NONHUMAN PRIMATES HAVE DEMONSTRATED AN INFLUENCE OF COCAINE ON BEHAVIOR, NO STUDIES HAVE YET EXAMINED WHETHER COCAINE AFFECTS SEXUAL BEHAVIOR IN NONHUMAN PRIMATES. THE OBJECTIVE OF THE PRESENT STUDY WAS TO EXAMINE TH ACUTE EFFECTS OF COCAINE ON MALE COPULATORY BEHAVIOR OF RHESUS MONKEYS. ADMINISTRATION OF COCAINE PRODUCED DOSE-DEPENDENT EFFECTS ON MALE COPULATORY BEHAVIOR, WITH MONKEYS TAKING SIGNIFICANTLY LONGER TO INITIATE COPULATION (MOUNT LATENCY) AND ACHIEVE AN EJACULATION(EJACULATION LATENCY) AFTER RECEIVING 200-800 MG/KG COCAINE. MALE COPULATORY BEHAVIOR WAS NOT AFFECTED BY COCAINE AT DOSES BELOW 200 MG/KG. THESE RESULTS INDICATE THAT COCAINE CAN ACUTELY IMPAIR SEXUAL BEHAVIOR PERFORMANCE OF MALE RHESUS MONKEYS. FURTHER STUDY IS NEEDED TO DETERMINE THE POSSIBLE LONG-TERM CONSEQUENCES OF CHRONIC COCAINE ADMINISTRATION ON MALE SEXUAL BEHAVIOR. |
| Dose amount | 25-99 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | MONKEY(RHESUS) |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |