Experiment 568796
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | YAMAGUCHI,Y: HARUTA,K: KOBAYASHI,H:. (1995). EFFECTS OF GINSENOSIDES ON IMPAIRED PERFORMANCE INDUCED IN THE RAT BY SCOPOLAMINE IN A RADIAL-ARM MAZE.. 20(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF GINSENOSIDES RG1, RD AND RB1 ON IMPAIRED PERFORMANCE INDUCED IN THE RAT BY SCOPOLAMINE WERE EXAMD. IN A RADIAL-ARM MAZE. SCOPOLAMINE CAUSED A REDUCTION IN THE NO. OF INITIAL CORRECT RESPONSES IN THE MAZE. A SINGLE IP INJECTION OF RG BUT NOT RD OR RB1, PREVENTED THE REDN. THE INHIBITION OF THE REDN. IN INITIAL CORRECT RESPONSES WAS ASSOCD. WITH A BELLSHAPED DOSE-RESPONSE CURVE FOR RG1. A LESION IN THE MEDIAL SEPTUM CAUSED SPATIAL LEARNING DEFICITS. RG1 DID NOT OVERCOME THESE DEFICITS. IT IS SUGGESTED THAT CHOLINERGIC NEURONS IN THE MEDIAL SEPTUM ARE INVOLVED IN THE AMELIORATIVE EFFECT OF RG1 ON IMPAIRED PERFORMANCE INDUCED BY SCOPOLAMINE. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |