| Disease | A PROCESS FOR THE PREPN. OF SERENOA REPENS EXTS. CONSISTING OF LONG-CHAIN SATD. AND UNSATD. STEROLIC AND TRITERPENIC ALCS., COMPRISES THE TREATMENT OF THE TOTAL LIPOPHILIC EXT. OF S.REPENS BY ALK. HYDROLYSIS IN HYDROALC. SOLVENT, FOLLOWED BY
FILTRATION, AND ESTN. OF THE FILTRATE WITH A WATER-IMMISCIBLE SOLVENT. THE TOTAL EXT. MAY OPTIONALLY BE PRUIFIED FROM ACIDIC COMPONENTS BY ELUTION FROM ION-EXCHANGE RESINS. FINELY GROUND S.REPENS FRUITS (1 KG) WERE EXTD. WITH N-HEHANE, THE
WAS EVAPD., AND THE RESIDUE (90 G) WAS TREATED WITH 4 L MEOH AND 1.2 L 2.5N KOH, THE MIXT. WAS FILTERED, AND THE FILTRATE WAS DILD. WITH 15 L H2O. THIS AQ. PHASE WAS EXTD. WITH CH2CL2 AND THE ORG.EXT WAS WASHED WITH 1NHCL, DRIED, AND THE SOLVENT
WAS REMOVED TO GIVE 3 G ALC. MIXT. WHICH WAS FRACTIONATED ON SILICA GEL. THE 1ST FRACTION CONSISTED OF FARNESOL, PHYTOL, GERANYLGERANIOL, N-C22H45OH, N-C23H47OH, N-C24H49OH, N-C26H53OH, AND N-C28H57OH, THE 2ND FRACTION CONTAINED STIGMASTEROL
ACETATE, BETA-SITOSTEROL, CYCLOARTENOL,LUPEOL, AND 24-METHYLENECYCLOARTENOL; A 3RD FRACTION CONTAINED POLYPRENOLS. TABLETS CONTAINED S.REPENS EXT 20, GRANULAR CELLULOSE 40, CROSPOVIDONE 20, NA CM-CELLULOSE 10, POLY(VINYLPYRROLIDONE) PM-30,000
3, COLLOIDAL SILICA 5, AND TALC 2 MG EACH. ORCHIETOMIZED RATS WERE TREATED FOR 5 DAYS S.C. WITH 12 MG TESTOSTERONE PROPIONATE AND 50 OF THE ALC. FRACTION OF S.REPENS EXT. OR WITH 400 MG TOTAL LIPOPHILIC S.REPENS EXT.; THE ALC. FRACTION,
ADMINISTERED AT A DOSE 8 TIMES LOWER THAN THAT OF THE TOTAL LIPOPHILIC EXT. INDUCED A LARGER DECREASE OF BOTH, THE WT. OF THE VENTRAL PROSTRATE AND THE SEMINAL VESICLES. THE ALC. FRACTIONS OF S.REPENS EXTS. MAY THUS BE USED TO TREAT BENIGN
PROSTATIC ADENOMA. |